| Primary HIV Infection |
|---|
- Asymptomatic
- Acute retroviral syndrome
|
| Clinical Stage 1 |
|---|
- Asymptomatic
- Persistent generalized lymphadenopathy
|
| Clinical Stage 2 |
|---|
- Moderate unexplained weight loss (<10% of presumed or measured body weight)
- Recurrent respiratory infections (sinusitis, tonsillitis, otitis media, and pharyngitis)
- Herpes zoster
- Angular cheilitis
- Recurrent oral ulceration
- Papular pruritic eruptions
- Seborrheic dermatitis
- Fungal nail infections
|
| Clinical Stage 3 |
|---|
- Unexplained severe weight loss (>10% of presumed or measured body weight)
- Unexplained chronic diarrhea for >1 month
- Unexplained persistent fever for >1 month (>37.6ºC, intermittent or constant)
- Persistent oral candidiasis (thrush)
- Oral hairy leukoplakia
- Pulmonary tuberculosis (current)
- Severe presumed bacterial infections (e.g., pneumonia, empyema, pyomyositis, bone or joint infection, meningitis, bacteremia)
- Acute necrotizing ulcerative stomatitis, gingivitis, or periodontitis
- Unexplained anemia (hemoglobin <8 g/dL)
- Neutropenia (neutrophils <500 cells/µL)
- Chronic thrombocytopenia (platelets <50,000 cells/µL)
|
| Clinical Stage 4 |
|---|
- HIV wasting syndrome, as defined by the CDC
- Pneumocystis pneumonia
- Recurrent severe bacterial pneumonia
- Chronic herpes simplex infection (orolabial, genital, or anorectal site for >1 month or visceral herpes at any site)
- Esophageal candidiasis (or candidiasis of trachea, bronchi, or lungs)
- Extrapulmonary tuberculosis
- Kaposi sarcoma
- Cytomegalovirus infection (retinitis or infection of other organs)
- Central nervous system toxoplasmosis
- HIV encephalopathy
- Cryptococcosis, extrapulmonary (including meningitis)
- Disseminated nontuberculosis mycobacteria infection
- Progressive multifocal leukoencephalopathy
- Candida of the trachea, bronchi, or lungs
- Chronic cryptosporidiosis (with diarrhea)
- Chronic isosporiasis
- Disseminated mycosis (e.g., histoplasmosis, coccidioidomycosis, penicilliosis)
- Recurrent nontyphoidal Salmonella bacteremia
- Lymphoma (cerebral or B-cell non-Hodgkin)
- Invasive cervical carcinoma
- Atypical disseminated leishmaniasis
- Symptomatic HIV-associated nephropathy
- Symptomatic HIV-associated cardiomyopathy
- Reactivation of American trypanosomiasis (meningoencephalitis or myocarditis)
|